Project

This action aims at training participants to the project, and notably the junior scientists (PhD, postdoc) hired in the project as well as students of the University of Lille but also at sharing knowledge and knowhow with academic and industrial scientists and allow that knowledge to be built upon to increase IMMENSE scientific and economic impacts.

WP coordinator: Dr. F. Pourpoint

Participants: BSI, Institut Chevreul, Lasire, LilNCog, PLBS, UCCS

• Task 1.1: Internal training
• Task 1.2: Strengthening higher education in Lille
• Task 1.3: External training activities for students, academic and industrial researchers
• Task 1.4 Scientific output publication and sharing
• Task 1.5 Conferences
• Task 1.6 The website
• Task 1.7 Social media outlets
• Task 1.8 Communication and public engagement strategy

Develop next generation ultra-sensitive MRI contrast agents to visualize AD-associated brain lesions with ultra-high field MRI scanners.

WP coordinator: Dr. X. Hanoulle

Participants: BSI, Institut Chevreul, LASIRE, LilNCog, PLBS

• Task 2.1 Contrast agents tailored for MRI at ultra-high fields
• Task 2.2 Contrast agents based on nanobodies targeting amyloid deposits
• Task 2.3 MRI of amyloid deposits using developed bio-conjugates
   

Enhancing resolution of NMR spectra acquired at low fields using AI-based tools trained on high-field NMR data.

WP coordinator: Dr. R. Lopes

Participants: BSI, Institut Chevreul, LilNCog, PLBS, UCCS

• Task 3.1 NMR spectra of cerebral metabolites with enhanced resolution
• Task 3.2 Extending AI-based resolution enhancement to other NMR spectra
• Task 3.3 Removing artifacts in pure shift 1H NMR using AI
   

Novel NMR pulse sequence for physiological mixture analysis and quantification for direct application in MRS of the human brain. There are three technical routes to explore, as subdivided in the different tasks below (4.1-4.3). Each task will follow a similar workflow: (1) design and optimize these methods using liquid-state NMR at high magnetic field, with the specific technical restrictions of MRS in mind; (2) adapt these sequences to include spatial selection elements; (3) evaluate/optimize them in vitro for quantification on physiological mixtures with protein background representative for what is found in the human brain; (4) implement these sequences on MRI instruments, adapting the experimental setup to the specific technical constraints of instruments. All methods will be benchmarked against existing MRS methods.

WP coordinator: Dr. D. Sinnaeve

Participants: BSI, Institut Chevreul, LilNCog, PLBS, UCCS

• Task 4.1 Develop ultrafast pure shift or chemical shift selective techniques
• Task 4.2 Develop ultrafast 2D techniques
• Task 4.3 Develop ultrafast diffusion and relaxation resolved techniques
   

Imaging of chemical transformations in commercial batteries and photovoltaic cells under operating conditions by combining MRI and EPR at high and low magnetic fields.

WP coordinator: Dr. H. Vezin

Participants: BSI, Institut Chevreul, Lasire, LilNCog, PLBS, UCCS

Task 5.1: MRI and EPR chemical imaging of commercial batteries
Task 5.2: Understanding aging of photovoltaic cells using MRI and EPR chemical imaging
 

Project Coordinator (PCo), assisted by deputy PCo, will implement the overall administrative management of IMMENSE.

WP coordinators: Pr. O. Lafon (PCo) and Dr. I. Landrieu (deputy PCo)

• Task 6.1: Administration of the project
• Task 6.2: Recruitment